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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C10H10N4O2S
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RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
250.278 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
1.883
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Dosage Forms
Cream
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Indication
For the treatment of rheumatic fever and meningococcal meningitis
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Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
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Absorption
No information avaliable
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Enteric bacteria and other eubacteria