Trifonamide
Brand names,
Trifonamide
Analogs
Trifonamide
Brand Names Mixture
Trifonamide
Chemical_Formula
C10H10N4O2S
Trifonamide
RX_link
http://www.rxlist.com/cgi/generic3/silversulf.htm
Trifonamide
fda sheet
Trifonamide
msds (material safety sheet)
Trifonamide
Synthesis Reference
No information avaliable
Trifonamide
Molecular Weight
250.278 g/mol
Trifonamide
Melting Point
No information avaliable
Trifonamide
H2O Solubility
No information avaliable
Trifonamide
State
Solid
Trifonamide
LogP
1.883
Trifonamide
Dosage Forms
Cream
Trifonamide
Indication
For the treatment of rheumatic fever and meningococcal meningitis
Trifonamide
Pharmacology
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Trifonamide
Absorption
No information avaliable
Trifonamide
side effects and Toxicity
No information avaliable
Trifonamide
Patient Information
No information avaliable
Trifonamide
Organisms Affected
Enteric bacteria and other eubacteria