Prophene 65
Brand names,
Prophene 65
Analogs
Prophene 65
Brand Names Mixture
Prophene 65
Chemical_Formula
C22H29NO2
Prophene 65
RX_link
http://www.rxlist.com/cgi/generic/propox.htm
Prophene 65
fda sheet
Prophene 65
msds (material safety sheet)
Prophene 65
Synthesis Reference
Pohland, U.S. Pat. 2,728,779 (1955)
Prophene 65
Molecular Weight
339.471 g/mol
Prophene 65
Melting Point
75-76oC
Prophene 65
H2O Solubility
19.6mg/L
Prophene 65
State
Solid
Prophene 65
LogP
4.901
Prophene 65
Dosage Forms
Tablet
Prophene 65
Indication
For the relief of mild to moderate pain
Prophene 65
Pharmacology
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli.
Prophene 65
Absorption
No information avaliable
Prophene 65
side effects and Toxicity
Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)
Prophene 65
Patient Information
Prophene 65
Organisms Affected
Humans and other mammals