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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C22H29NO2
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RX_link
http://www.rxlist.com/cgi/generic/propox.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Pohland, U.S. Pat. 2,728,779 (1955)
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Molecular Weight
339.471 g/mol
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Melting Point
75-76oC
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H2O Solubility
19.6mg/L
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State
Solid
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LogP
4.901
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Dosage Forms
Tablet
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Indication
For the relief of mild to moderate pain
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Pharmacology
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli.
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Absorption
No information avaliable
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side effects and Toxicity
Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)
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Patient Information
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Organisms Affected
Humans and other mammals