Harmar
Brand names,
Harmar
Analogs
Harmar
Brand Names Mixture
Harmar
Chemical_Formula
C22H29NO2
Harmar
RX_link
http://www.rxlist.com/cgi/generic/propox.htm
Harmar
fda sheet
Harmar
msds (material safety sheet)
Harmar
Synthesis Reference
Pohland, U.S. Pat. 2,728,779 (1955)
Harmar
Molecular Weight
339.471 g/mol
Harmar
Melting Point
75-76oC
Harmar
H2O Solubility
19.6mg/L
Harmar
State
Solid
Harmar
LogP
4.901
Harmar
Dosage Forms
Tablet
Harmar
Indication
For the relief of mild to moderate pain
Harmar
Pharmacology
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli.
Harmar
Absorption
No information avaliable
Harmar
side effects and Toxicity
Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)
Harmar
Patient Information
Harmar
Organisms Affected
Humans and other mammals