D-Propoxyphene
D-Propoxyphene Brand names, D-Propoxyphene Analogs
D-Propoxyphene Brand Names Mixture
- No information avaliable
D-Propoxyphene Chemical_Formula
C22H29NO2
D-Propoxyphene RX_link
http://www.rxlist.com/cgi/generic/propox.htm
D-Propoxyphene fda sheet
D-Propoxyphene msds (material safety sheet)
D-Propoxyphene Synthesis Reference
Pohland, U.S. Pat. 2,728,779 (1955)
D-Propoxyphene Molecular Weight
339.471 g/mol
D-Propoxyphene Melting Point
75-76oC
D-Propoxyphene H2O Solubility
19.6mg/L
D-Propoxyphene State
Solid
D-Propoxyphene LogP
4.901
D-Propoxyphene Dosage Forms
Tablet
D-Propoxyphene Indication
For the relief of mild to moderate pain
D-Propoxyphene Pharmacology
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli.
D-Propoxyphene Absorption
No information avaliable
D-Propoxyphene side effects and Toxicity
Coma, respiratory depression, circulatory collapse, and pulmonary edema. Seizures occur more frequently in patients with propoxyphene intoxication than in those with opiate intoxication. LD50=230mg/kg (orally in rat, Emerson)
D-Propoxyphene Patient Information
D-Propoxyphene Organisms Affected
Humans and other mammals
