Pethidine
Pethidine Brand names, Pethidine Analogs
Pethidine Brand Names Mixture
- No information avaliable
Pethidine Chemical_Formula
C15H21NO2
Pethidine RX_link
http://www.rxlist.com/cgi/generic/meper.htm
Pethidine fda sheet
Pethidine msds (material safety sheet)
Pethidine Synthesis Reference
No information avaliable
Pethidine Molecular Weight
247.333 g/mol
Pethidine Melting Point
186 - 189 oC
Pethidine H2O Solubility
3220 mg/L
Pethidine State
Solid
Pethidine LogP
3.303
Pethidine Dosage Forms
Syrup; Tablet
Pethidine Indication
Used to control moderate to severe pain.
Pethidine Pharmacology
Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class. Meperidine may produce less smooth muscle spasm, constipation, and depression of the cough reflex than equivalent doses of morphine. The onset of action is lightly more rapid than with morphine, and the duration of action is slightly shorter. The chemical structure of meperidine is similar to local anesthetics. Meperidine is recommended for relief of moderate to severe acute pain and has the unique ability to interrupt postoperative shivering and shaking chills induced by amphotericin B. Meperidine has also been used for intravenous regional anesthesia, peripheral nerve blocks and intraarticular, epidural and spinal analgesia. Meperidine is considered a second-line agent for the treatment of acute pain.
Pethidine Absorption
Oral bioavailability is 50-60% in patients with normal hepatic function.
Pethidine side effects and Toxicity
No information avaliable
Pethidine Patient Information
No information avaliable
Pethidine Organisms Affected
Humans and other mammals
