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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C8H7N3O5
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RX_link
http://www.rxlist.com/cgi/generic2/furazol.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
225.158 g/mol
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Melting Point
255 oC
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H2O Solubility
40 mg/L
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State
Solid
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LogP
0.691
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Dosage Forms
Tablets; Liquid
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Indication
For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
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Pharmacology
Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is based upon its interference with DNA replication and protein production; this antimicrobial action minimizes the development of resistant organisms.
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Absorption
Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration
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side effects and Toxicity
Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors.
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Patient Information
No information avaliable
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Organisms Affected
Microbes (bacteria, parasites)