PharmacyCodes



Thenobarbital en es it fr

Thenobarbital Brand names, Thenobarbital Analogs

Thenobarbital Brand Names Mixture

  • No information avaliable

Thenobarbital Chemical_Formula

C12H12N2O3

Thenobarbital RX_link

No information avaliable

Thenobarbital fda sheet

Thenobarbital msds (material safety sheet)

Thenobarbital MSDS

Thenobarbital Synthesis Reference

Hoerlein, U.S. Pat. 1,025,872 (1912)

Thenobarbital Molecular Weight

232.235 g/mol

Thenobarbital Melting Point

174 oC

Thenobarbital H2O Solubility

<0.01 g/100 mL

Thenobarbital State

Solid

Thenobarbital LogP

1.777

Thenobarbital Dosage Forms

Tablet; Elixir

Thenobarbital Indication

For the treatment of Epilepsy

Thenobarbital Pharmacology

Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).

Thenobarbital Absorption

Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach

Thenobarbital side effects and Toxicity

CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.

Thenobarbital Patient Information

PATIENT INFORMATION

Practitioners should give the following information and instructions to patients receiving barbiturates:

1. The use of phenobarbital carries with it an associated risk of psychological and/or physical dependence.
The patient should be warned against increasing the dose of the drug without consulting a physician.

2. Phenobarbital may impair mental and/or physical abilities required for the performance of potentially
hazardous tasks (e.g., driving, operating machinery, etc.).

3. Alcohol should not be consumed while taking phenobarbital. Concurrent use of phenobarbital with other
CNS depressants (e.g., alcohol, narcotics, tranquilizers, and antihistamines) may result in additional CNS
depressant

Thenobarbital Organisms Affected

Humans and other mammals