Bartol
Brand names,
Bartol
Analogs
Bartol
Brand Names Mixture
Bartol
Chemical_Formula
C12H12N2O3
Bartol
RX_link
No information avaliable
Bartol
fda sheet
Bartol
msds (material safety sheet)
Bartol
Synthesis Reference
Hoerlein, U.S. Pat. 1,025,872 (1912)
Bartol
Molecular Weight
232.235 g/mol
Bartol
Melting Point
174 oC
Bartol
H2O Solubility
<0.01 g/100 mL
Bartol
State
Solid
Bartol
LogP
1.777
Bartol
Dosage Forms
Tablet; Elixir
Bartol
Indication
For the treatment of Epilepsy
Bartol
Pharmacology
Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).
Bartol
Absorption
Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach
Bartol
side effects and Toxicity
CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
Bartol
Patient Information
PATIENT INFORMATION
Practitioners should give the following information and instructions to patients receiving barbiturates:
1. The use of phenobarbital carries with it an associated risk of psychological and/or physical dependence.
The patient should be warned against increasing the dose of the drug without consulting a physician.
2. Phenobarbital may impair mental and/or physical abilities required for the performance of potentially
hazardous tasks (e.g., driving, operating machinery, etc.).
3. Alcohol should not be consumed while taking phenobarbital. Concurrent use of phenobarbital with other
CNS depressants (e.g., alcohol, narcotics, tranquilizers, and antihistamines) may result in additional CNS
depressant
Bartol
Organisms Affected
Humans and other mammals