Calminal
Brand names,
Calminal
Analogs
Calminal
Brand Names Mixture
Calminal
Chemical_Formula
C12H12N2O3
Calminal
RX_link
No information avaliable
Calminal
fda sheet
Calminal
msds (material safety sheet)
Calminal
Synthesis Reference
Hoerlein, U.S. Pat. 1,025,872 (1912)
Calminal
Molecular Weight
232.235 g/mol
Calminal
Melting Point
174 oC
Calminal
H2O Solubility
<0.01 g/100 mL
Calminal
State
Solid
Calminal
LogP
1.777
Calminal
Dosage Forms
Tablet; Elixir
Calminal
Indication
For the treatment of Epilepsy
Calminal
Pharmacology
Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal).
Calminal
Absorption
Absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach
Calminal
side effects and Toxicity
CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may wshow paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.
Calminal
Patient Information
PATIENT INFORMATION
Practitioners should give the following information and instructions to patients receiving barbiturates:
1. The use of phenobarbital carries with it an associated risk of psychological and/or physical dependence.
The patient should be warned against increasing the dose of the drug without consulting a physician.
2. Phenobarbital may impair mental and/or physical abilities required for the performance of potentially
hazardous tasks (e.g., driving, operating machinery, etc.).
3. Alcohol should not be consumed while taking phenobarbital. Concurrent use of phenobarbital with other
CNS depressants (e.g., alcohol, narcotics, tranquilizers, and antihistamines) may result in additional CNS
depressant
Calminal
Organisms Affected
Humans and other mammals