Tegopen
Tegopen Brand names, Tegopen Analogs
Tegopen Brand Names Mixture
- No information avaliable
Tegopen Chemical_Formula
C47H73NO17
Tegopen RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Tegopen fda sheet
Tegopen msds (material safety sheet)
Tegopen Synthesis Reference
No information avaliable
Tegopen Molecular Weight
924.079 g/mol
Tegopen Melting Point
170.0 oC
Tegopen H2O Solubility
750 mg/L
Tegopen State
Solid
Tegopen LogP
0.947
Tegopen Dosage Forms
Slow intravenous-infusion
Tegopen Indication
Used to treat potentially life threatening fungal infections.
Tegopen Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Tegopen Absorption
Bioavailability is 100% for intravenous infusion.
Tegopen side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Tegopen Patient Information
No information avaliable
Tegopen Organisms Affected
Various Fungus Species
