Amphortericin B

Amphortericin B Brand names, Amphortericin B Analogs

Amphortericin B Brand Names Mixture

No information avaliable

Amphortericin B Chemical_Formula

C₄₇H₇₃NO₁₇

Amphortericin B RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

Amphortericin B fda sheet

Amphortericin_B FDA

Amphortericin B msds (material safety sheet)

Amphortericin_B MSDS

Amphortericin B Synthesis Reference

No information avaliable

Amphortericin B Molecular Weight

924.079 g/mol

Amphortericin B Melting Point

170.0 ^oC

Amphortericin B H₂O Solubility

750 mg/L

Amphortericin B State

Solid

Amphortericin B LogP

0.947

Amphortericin B Dosage Forms

Slow intravenous-infusion

Amphortericin B Indication

Used to treat potentially life threatening fungal infections.

Amphortericin B Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

Amphortericin B Absorption

Bioavailability is 100% for intravenous infusion.

Amphortericin B side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

Amphortericin B Patient Information