AmBisome

AmBisome Brand names, AmBisome Analogs

AmBisome Brand Names Mixture

No information avaliable

AmBisome Chemical_Formula

C₄₇H₇₃NO₁₇

AmBisome RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

AmBisome fda sheet

AmBisome FDA

AmBisome msds (material safety sheet)

AmBisome MSDS

AmBisome Synthesis Reference

No information avaliable

AmBisome Molecular Weight

924.079 g/mol

AmBisome Melting Point

170.0 ^oC

AmBisome H₂O Solubility

750 mg/L

AmBisome State

Solid

AmBisome LogP

0.947

AmBisome Dosage Forms

Slow intravenous-infusion

AmBisome Indication

Used to treat potentially life threatening fungal infections.

AmBisome Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

AmBisome Absorption

Bioavailability is 100% for intravenous infusion.

AmBisome side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

AmBisome Patient Information