IAB

IAB Brand names, IAB Analogs

IAB Brand Names Mixture

No information avaliable

IAB Chemical_Formula

C₄₇H₇₃NO₁₇

IAB RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

IAB fda sheet

IAB FDA

IAB msds (material safety sheet)

IAB MSDS

IAB Synthesis Reference

No information avaliable

IAB Molecular Weight

924.079 g/mol

IAB Melting Point

170.0 ^oC

IAB H₂O Solubility

750 mg/L

IAB State

Solid

IAB LogP

0.947

IAB Dosage Forms

Slow intravenous-infusion

IAB Indication

Used to treat potentially life threatening fungal infections.

IAB Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

IAB Absorption

Bioavailability is 100% for intravenous infusion.

IAB side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

IAB Patient Information