LNS-AmB

LNS-AmB Brand names, LNS-AmB Analogs

LNS-AmB Brand Names Mixture

No information avaliable

LNS-AmB Chemical_Formula

C₄₇H₇₃NO₁₇

LNS-AmB RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

LNS-AmB fda sheet

LNS-AmB FDA

LNS-AmB msds (material safety sheet)

LNS-AmB MSDS

LNS-AmB Synthesis Reference

No information avaliable

LNS-AmB Molecular Weight

924.079 g/mol

LNS-AmB Melting Point

170.0 ^oC

LNS-AmB H₂O Solubility

750 mg/L

LNS-AmB State

Solid

LNS-AmB LogP

0.947

LNS-AmB Dosage Forms

Slow intravenous-infusion

LNS-AmB Indication

Used to treat potentially life threatening fungal infections.

LNS-AmB Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

LNS-AmB Absorption

Bioavailability is 100% for intravenous infusion.

LNS-AmB side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

LNS-AmB Patient Information