Amphotec

Amphotec Brand names, Amphotec Analogs

Amphotec Brand Names Mixture

No information avaliable

Amphotec Chemical_Formula

C₄₇H₇₃NO₁₇

Amphotec RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

Amphotec fda sheet

Amphotec FDA

Amphotec msds (material safety sheet)

Amphotec MSDS

Amphotec Synthesis Reference

No information avaliable

Amphotec Molecular Weight

924.079 g/mol

Amphotec Melting Point

170.0 ^oC

Amphotec H₂O Solubility

750 mg/L

Amphotec State

Solid

Amphotec LogP

0.947

Amphotec Dosage Forms

Slow intravenous-infusion

Amphotec Indication

Used to treat potentially life threatening fungal infections.

Amphotec Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

Amphotec Absorption

Bioavailability is 100% for intravenous infusion.

Amphotec side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

Amphotec Patient Information