Liposomal Amphotericin B

Liposomal Amphotericin B Brand names, Liposomal Amphotericin B Analogs

Liposomal Amphotericin B Brand Names Mixture

No information avaliable

Liposomal Amphotericin B Chemical_Formula

C₄₇H₇₃NO₁₇

Liposomal Amphotericin B RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

Liposomal Amphotericin B fda sheet

Liposomal_Amphotericin_B FDA

Liposomal Amphotericin B msds (material safety sheet)

Liposomal_Amphotericin_B MSDS

Liposomal Amphotericin B Synthesis Reference

No information avaliable

Liposomal Amphotericin B Molecular Weight

924.079 g/mol

Liposomal Amphotericin B Melting Point

170.0 ^oC

Liposomal Amphotericin B H₂O Solubility

750 mg/L

Liposomal Amphotericin B State

Solid

Liposomal Amphotericin B LogP

0.947

Liposomal Amphotericin B Dosage Forms

Slow intravenous-infusion

Liposomal Amphotericin B Indication

Used to treat potentially life threatening fungal infections.

Liposomal Amphotericin B Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

Liposomal Amphotericin B Absorption

Bioavailability is 100% for intravenous infusion.

Liposomal Amphotericin B side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

Liposomal Amphotericin B Patient Information