Amphotericine B

Amphotericine B Brand names, Amphotericine B Analogs

Amphotericine B Brand Names Mixture

No information avaliable

Amphotericine B Chemical_Formula

C₄₇H₇₃NO₁₇

Amphotericine B RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

Amphotericine B fda sheet

Amphotericine_B FDA

Amphotericine B msds (material safety sheet)

Amphotericine_B MSDS

Amphotericine B Synthesis Reference

No information avaliable

Amphotericine B Molecular Weight

924.079 g/mol

Amphotericine B Melting Point

170.0 ^oC

Amphotericine B H₂O Solubility

750 mg/L

Amphotericine B State

Solid

Amphotericine B LogP

0.947

Amphotericine B Dosage Forms

Slow intravenous-infusion

Amphotericine B Indication

Used to treat potentially life threatening fungal infections.

Amphotericine B Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

Amphotericine B Absorption

Bioavailability is 100% for intravenous infusion.

Amphotericine B side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

Amphotericine B Patient Information