Fungizone Intravenous
Brand names,
Fungizone Intravenous
Analogs
Fungizone Intravenous
Brand Names Mixture
Fungizone Intravenous
Chemical_Formula
C47H73NO17
Fungizone Intravenous
RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Fungizone Intravenous
fda sheet
Fungizone Intravenous
msds (material safety sheet)
Fungizone Intravenous
Synthesis Reference
No information avaliable
Fungizone Intravenous
Molecular Weight
924.079 g/mol
Fungizone Intravenous
Melting Point
170.0 oC
Fungizone Intravenous
H2O Solubility
750 mg/L
Fungizone Intravenous
State
Solid
Fungizone Intravenous
LogP
0.947
Fungizone Intravenous
Dosage Forms
Slow intravenous-infusion
Fungizone Intravenous
Indication
Used to treat potentially life threatening fungal infections.
Fungizone Intravenous
Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Fungizone Intravenous
Absorption
Bioavailability is 100% for intravenous infusion.
Fungizone Intravenous
side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Fungizone Intravenous
Patient Information
No information avaliable
Fungizone Intravenous
Organisms Affected
Various Fungus Species