HSDB 3008 IAB

HSDB 3008 IAB Brand names, HSDB 3008 IAB Analogs

HSDB 3008 IAB Brand Names Mixture

No information avaliable

HSDB 3008 IAB Chemical_Formula

C₄₇H₇₃NO₁₇

HSDB 3008 IAB RX_link

http://www.rxlist.com/cgi/generic2/amphoter.htm

HSDB 3008 IAB fda sheet

HSDB_3008_IAB FDA

HSDB 3008 IAB msds (material safety sheet)

HSDB_3008_IAB MSDS

HSDB 3008 IAB Synthesis Reference

No information avaliable

HSDB 3008 IAB Molecular Weight

924.079 g/mol

HSDB 3008 IAB Melting Point

170.0 ^oC

HSDB 3008 IAB H₂O Solubility

750 mg/L

HSDB 3008 IAB State

Solid

HSDB 3008 IAB LogP

0.947

HSDB 3008 IAB Dosage Forms

Slow intravenous-infusion

HSDB 3008 IAB Indication

Used to treat potentially life threatening fungal infections.

HSDB 3008 IAB Pharmacology

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

HSDB 3008 IAB Absorption

Bioavailability is 100% for intravenous infusion.

HSDB 3008 IAB side effects and Toxicity

Oral, rat: LD₅₀ = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

HSDB 3008 IAB Patient Information