Sklerolip
Sklerolip Brand names, Sklerolip Analogs
- Abitrate
- Amotril
- Amotril S
- Angiokapsul
- Anparton
- Antilipid
- Antilipide
- Apolan
- Arterioflexin
- Arterosol
- Artes
- Artevil
- Ateculon
- Ateriosan
- Athebrate
- Atheromide
- Atheropront
- Athranid-Wirkstoff
- Atrolen
- Atromid
- Atromid S
- Atromid-S
- Atromida
- Atromidin
- Atrovis
- Azionyl
- Bioscleran
- Bresit
- CPIB
- Cartagyl
- Chlorfenisate
- Chlorophenoxyisobutyricacidethylester
- Chlorphenisate
- Cinnarizin
- Cinnarizine
- Citiflus
- Claripex
- Claripex CPIB
- Cloberat
- Clobrat
- Clobren-5F
- Clobren-SF
- Clofar
- Clofibate
- Clofibram
- Clofibrat
- Clofibrato
- Clofibratum
- Clofinit
- Clofipront
- Delipid
- Deliva
- Dura clofibrat
- ELPI
- EPIB
- Ethyl chlorophenoxyisobutyrate
- Ethyl clofibrate
- Ethyl p-chlorophenoxyisobutyrate
- Ethyl para-chlorophenoxyisobutyrate
- Fibralem
- Gerastop
- Hyclorate
- Klofibrat
- Klofiran
- Levatrom
- Lipamid
- Lipavil
- Lipavlon
- Lipide 500
- Lipidsenker
- Lipofacton
- Lipomid
- Liponorm
- Liporeduct
- Liporil
- Liposid
- Liprin
- Liprinal
- Lobetrin
- Miscleron
- Negalip
- Neo-Atromid
- Normalip
- Normat
- Normet
- Normolipol
- Novofibrate
- Oxan 600
- Persantinat
- Recolip
- Regardin
- Regelan
- Regelan N
- Robigram
- Scrobin
- Serofinex
- Serotinex
- Skerolip
- Sklerepmexe
- Sklero
- Sklero-Tablinen
- Sklero-tablinene
- Sklero-tabuls
- Sklerolip
- Skleromex
- Skleromexe
- Tetrasipton
- Thillate
- Thiosan
- Ticlobran
- Vincamin compositum
- Xyduril
- Yoclo
- neo-Atomid
Sklerolip Brand Names Mixture
- No information avaliable
Sklerolip Chemical_Formula
C12H15ClO3
Sklerolip RX_link
http://www.rxlist.com/cgi/generic2/clofibrate.htm
Sklerolip fda sheet
Sklerolip msds (material safety sheet)
Sklerolip Synthesis Reference
No information avaliable
Sklerolip Molecular Weight
242.698 g/mol
Sklerolip Melting Point
< 25 oC (boiling point 148-150°C at 25 mm Hg)
Sklerolip H2O Solubility
Insoluble
Sklerolip State
Liquid
Sklerolip LogP
3.58
Sklerolip Dosage Forms
Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)
Sklerolip Indication
For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.
Sklerolip Pharmacology
Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.
Sklerolip Absorption
Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.
Sklerolip side effects and Toxicity
Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.
Sklerolip Patient Information
Sklerolip Organisms Affected
Humans and other mammals
