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Athranid-Wirkstoff Brand names, Athranid-Wirkstoff Analogs

Athranid-Wirkstoff Brand Names Mixture

  • No information avaliable

Athranid-Wirkstoff Chemical_Formula


Athranid-Wirkstoff RX_link

Athranid-Wirkstoff fda sheet

Athranid-Wirkstoff msds (material safety sheet)

Athranid-Wirkstoff MSDS

Athranid-Wirkstoff Synthesis Reference

No information avaliable

Athranid-Wirkstoff Molecular Weight

242.698 g/mol

Athranid-Wirkstoff Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Athranid-Wirkstoff H2O Solubility


Athranid-Wirkstoff State


Athranid-Wirkstoff LogP


Athranid-Wirkstoff Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Athranid-Wirkstoff Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Athranid-Wirkstoff Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Athranid-Wirkstoff Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Athranid-Wirkstoff side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Athranid-Wirkstoff Patient Information

Athranid-Wirkstoff Organisms Affected

Humans and other mammals