Angiokapsul en es it fr

Angiokapsul Brand names, Angiokapsul Analogs

Angiokapsul Brand Names Mixture

  • No information avaliable

Angiokapsul Chemical_Formula


Angiokapsul RX_link

Angiokapsul fda sheet

Angiokapsul msds (material safety sheet)

Angiokapsul MSDS

Angiokapsul Synthesis Reference

No information avaliable

Angiokapsul Molecular Weight

242.698 g/mol

Angiokapsul Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Angiokapsul H2O Solubility


Angiokapsul State


Angiokapsul LogP


Angiokapsul Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Angiokapsul Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Angiokapsul Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Angiokapsul Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Angiokapsul side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Angiokapsul Patient Information

Angiokapsul Organisms Affected

Humans and other mammals