Atromidin
Brand names,
Atromidin
Analogs
Atromidin
Brand Names Mixture
Atromidin
Chemical_Formula
C12H15ClO3
Atromidin
RX_link
http://www.rxlist.com/cgi/generic2/clofibrate.htm
Atromidin
fda sheet
Atromidin
msds (material safety sheet)
Atromidin
Synthesis Reference
No information avaliable
Atromidin
Molecular Weight
242.698 g/mol
Atromidin
Melting Point
< 25 oC (boiling point 148-150°C at 25 mm Hg)
Atromidin
H2O Solubility
Insoluble
Atromidin
State
Liquid
Atromidin
LogP
3.58
Atromidin
Dosage Forms
Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)
Atromidin
Indication
For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.
Atromidin
Pharmacology
Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.
Atromidin
Absorption
Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.
Atromidin
side effects and Toxicity
Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.
Atromidin
Patient Information
Atromidin
Organisms Affected
Humans and other mammals