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Bresit Brand names, Bresit Analogs

Bresit Brand Names Mixture

  • No information avaliable

Bresit Chemical_Formula

C12H15ClO3

Bresit RX_link

http://www.rxlist.com/cgi/generic2/clofibrate.htm

Bresit fda sheet

Bresit msds (material safety sheet)

Bresit MSDS

Bresit Synthesis Reference

No information avaliable

Bresit Molecular Weight

242.698 g/mol

Bresit Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Bresit H2O Solubility

Insoluble

Bresit State

Liquid

Bresit LogP

3.58

Bresit Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Bresit Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Bresit Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Bresit Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Bresit side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Bresit Patient Information

Bresit Organisms Affected

Humans and other mammals