Liponorm
Liponorm Brand names, Liponorm Analogs
Liponorm Brand Names Mixture
- No information avaliable
Liponorm Chemical_Formula
C25H38O5
Liponorm RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Liponorm fda sheet
Liponorm msds (material safety sheet)
Liponorm Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Liponorm Molecular Weight
418.566 g/mol
Liponorm Melting Point
135-138oC
Liponorm H2O Solubility
0.76 mg/L
Liponorm State
Solid
Liponorm LogP
4.937
Liponorm Dosage Forms
Tablet (oral)
Liponorm Indication
For the treatment of hypercholesterolemia.
Liponorm Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Liponorm Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Liponorm side effects and Toxicity
No information avaliable
Liponorm Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Liponorm Organisms Affected
Humans and other mammals
