Lipide 500 en es it fr

Lipide 500 Brand names, Lipide 500 Analogs

Lipide 500 Brand Names Mixture

  • No information avaliable

Lipide 500 Chemical_Formula


Lipide 500 RX_link

Lipide 500 fda sheet

Lipide 500 msds (material safety sheet)

Lipide_500 MSDS

Lipide 500 Synthesis Reference

No information avaliable

Lipide 500 Molecular Weight

242.698 g/mol

Lipide 500 Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Lipide 500 H2O Solubility


Lipide 500 State


Lipide 500 LogP


Lipide 500 Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Lipide 500 Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Lipide 500 Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Lipide 500 Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Lipide 500 side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Lipide 500 Patient Information

Lipide 500 Organisms Affected

Humans and other mammals