PharmacyCodes



Oxan 600 en es it fr

Oxan 600 Brand names, Oxan 600 Analogs

Oxan 600 Brand Names Mixture

  • No information avaliable

Oxan 600 Chemical_Formula

C12H15ClO3

Oxan 600 RX_link

http://www.rxlist.com/cgi/generic2/clofibrate.htm

Oxan 600 fda sheet

Oxan 600 msds (material safety sheet)

Oxan_600 MSDS

Oxan 600 Synthesis Reference

No information avaliable

Oxan 600 Molecular Weight

242.698 g/mol

Oxan 600 Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Oxan 600 H2O Solubility

Insoluble

Oxan 600 State

Liquid

Oxan 600 LogP

3.58

Oxan 600 Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Oxan 600 Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Oxan 600 Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Oxan 600 Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Oxan 600 side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Oxan 600 Patient Information

Oxan 600 Organisms Affected

Humans and other mammals