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Athebrate Brand names, Athebrate Analogs

Athebrate Brand Names Mixture

  • No information avaliable

Athebrate Chemical_Formula

C12H15ClO3

Athebrate RX_link

http://www.rxlist.com/cgi/generic2/clofibrate.htm

Athebrate fda sheet

Athebrate msds (material safety sheet)

Athebrate MSDS

Athebrate Synthesis Reference

No information avaliable

Athebrate Molecular Weight

242.698 g/mol

Athebrate Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Athebrate H2O Solubility

Insoluble

Athebrate State

Liquid

Athebrate LogP

3.58

Athebrate Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Athebrate Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Athebrate Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Athebrate Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Athebrate side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Athebrate Patient Information

Athebrate Organisms Affected

Humans and other mammals