Dura clofibrat en es it fr

Dura clofibrat Brand names, Dura clofibrat Analogs

Dura clofibrat Brand Names Mixture

  • No information avaliable

Dura clofibrat Chemical_Formula


Dura clofibrat RX_link


Dura clofibrat fda sheet

Dura clofibrat msds (material safety sheet)

Dura_clofibrat MSDS

Dura clofibrat Synthesis Reference

No information avaliable

Dura clofibrat Molecular Weight

242.698 g/mol

Dura clofibrat Melting Point

< 25 oC (boiling point 148-150°C at 25 mm Hg)

Dura clofibrat H2O Solubility


Dura clofibrat State


Dura clofibrat LogP


Dura clofibrat Dosage Forms

Capsules (orange, oblong, soft-gelatin capsules, each containing 500 mg clofibrate)

Dura clofibrat Indication

For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet.

Dura clofibrat Pharmacology

Clofibrate is an antilipidemic agent similar to gemfibrozil. It acts to lower elevated serum lipids by reducing the very low-density lipoprotein fraction (Sf 20-400) rich in triglycerides. Serum cholesterol may be decreased, particularly in those patients whose cholesterol elevation is due to the presence of IDL as a result of Type III hyperlipoproteinemia. Several investigators have observed in their studies that clofibrate may produce a decrease in cholesterol linoleate but an increase in palmitoleate and oleate, the latter being considered atherogenic in experimental animals. The significance of this finding is unknown at this time. Reduction of triglycerides in some patients treated with clofibrate or certain of its chemically and clinically similar analogs may be associated with an increase in LDL cholesterol. Increase in LDL cholesterol has been observed in patients whose cholesterol is initially normal. Animal studies suggest that clofibrate interrupts cholesterol biosynthesis prior to mevalonate formation.

Dura clofibrat Absorption

Completely but slowly absorbed from the intestine. Between 95% and 99% of an oral dose of clofibrate is excreted in the urine as free and conjugated clofibric acid; thus, the absorption of clofibrate is virtually complete.

Dura clofibrat side effects and Toxicity

Oral, mouse: LD50 = 1220 mg/kg; Oral, rabbit: LD50 = 1370 mg/kg; Oral, rat: LD50 = 940 mg/kg. No reported case of overdosage in humans.

Dura clofibrat Patient Information

Dura clofibrat Organisms Affected

Humans and other mammals