Simvastatin
Simvastatin Brand names, Simvastatin Analogs
Simvastatin Brand Names Mixture
- No information avaliable
Simvastatin Chemical_Formula
C25H38O5
Simvastatin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Simvastatin fda sheet
Simvastatin msds (material safety sheet)
Simvastatin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Simvastatin Molecular Weight
418.566 g/mol
Simvastatin Melting Point
135-138oC
Simvastatin H2O Solubility
0.76 mg/L
Simvastatin State
Solid
Simvastatin LogP
4.937
Simvastatin Dosage Forms
Tablet (oral)
Simvastatin Indication
For the treatment of hypercholesterolemia.
Simvastatin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Simvastatin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Simvastatin side effects and Toxicity
No information avaliable
Simvastatin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Simvastatin Organisms Affected
Humans and other mammals
