Sivastin
Sivastin Brand names, Sivastin Analogs
Sivastin Brand Names Mixture
- No information avaliable
Sivastin Chemical_Formula
C25H38O5
Sivastin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Sivastin fda sheet
Sivastin msds (material safety sheet)
Sivastin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Sivastin Molecular Weight
418.566 g/mol
Sivastin Melting Point
135-138oC
Sivastin H2O Solubility
0.76 mg/L
Sivastin State
Solid
Sivastin LogP
4.937
Sivastin Dosage Forms
Tablet (oral)
Sivastin Indication
For the treatment of hypercholesterolemia.
Sivastin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Sivastin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Sivastin side effects and Toxicity
No information avaliable
Sivastin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Sivastin Organisms Affected
Humans and other mammals
