Coledis
Coledis Brand names, Coledis Analogs
Coledis Brand Names Mixture
- No information avaliable
Coledis Chemical_Formula
C25H38O5
Coledis RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Coledis fda sheet
Coledis msds (material safety sheet)
Coledis Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Coledis Molecular Weight
418.566 g/mol
Coledis Melting Point
135-138oC
Coledis H2O Solubility
0.76 mg/L
Coledis State
Solid
Coledis LogP
4.937
Coledis Dosage Forms
Tablet (oral)
Coledis Indication
For the treatment of hypercholesterolemia.
Coledis Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Coledis Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Coledis side effects and Toxicity
No information avaliable
Coledis Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Coledis Organisms Affected
Humans and other mammals
