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Labistatin Brand names, Labistatin Analogs

Labistatin Brand Names Mixture

  • No information avaliable

Labistatin Chemical_Formula

C25H38O5

Labistatin RX_link

http://www.rxlist.com/cgi/generic/simva.htm

Labistatin fda sheet

Labistatin FDA

Labistatin msds (material safety sheet)

Labistatin Synthesis Reference

W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)

Labistatin Molecular Weight

418.566 g/mol

Labistatin Melting Point

135-138oC

Labistatin H2O Solubility

0.76 mg/L

Labistatin State

Solid

Labistatin LogP

4.937

Labistatin Dosage Forms

Tablet (oral)

Labistatin Indication

For the treatment of hypercholesterolemia.

Labistatin Pharmacology

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Labistatin Absorption

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.

Labistatin side effects and Toxicity

No information avaliable

Labistatin Patient Information

Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.

Labistatin Organisms Affected

Humans and other mammals