Labistatin
Labistatin Brand names, Labistatin Analogs
Labistatin Brand Names Mixture
- No information avaliable
Labistatin Chemical_Formula
C25H38O5
Labistatin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Labistatin fda sheet
Labistatin msds (material safety sheet)
Labistatin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Labistatin Molecular Weight
418.566 g/mol
Labistatin Melting Point
135-138oC
Labistatin H2O Solubility
0.76 mg/L
Labistatin State
Solid
Labistatin LogP
4.937
Labistatin Dosage Forms
Tablet (oral)
Labistatin Indication
For the treatment of hypercholesterolemia.
Labistatin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Labistatin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Labistatin side effects and Toxicity
No information avaliable
Labistatin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Labistatin Organisms Affected
Humans and other mammals
