Medipo
Medipo Brand names, Medipo Analogs
Medipo Brand Names Mixture
- No information avaliable
Medipo Chemical_Formula
C25H38O5
Medipo RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Medipo fda sheet
Medipo msds (material safety sheet)
Medipo Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Medipo Molecular Weight
418.566 g/mol
Medipo Melting Point
135-138oC
Medipo H2O Solubility
0.76 mg/L
Medipo State
Solid
Medipo LogP
4.937
Medipo Dosage Forms
Tablet (oral)
Medipo Indication
For the treatment of hypercholesterolemia.
Medipo Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Medipo Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Medipo side effects and Toxicity
No information avaliable
Medipo Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Medipo Organisms Affected
Humans and other mammals
