Synvinolin
Synvinolin Brand names, Synvinolin Analogs
Synvinolin Brand Names Mixture
- No information avaliable
Synvinolin Chemical_Formula
C25H38O5
Synvinolin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Synvinolin fda sheet
Synvinolin msds (material safety sheet)
Synvinolin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Synvinolin Molecular Weight
418.566 g/mol
Synvinolin Melting Point
135-138oC
Synvinolin H2O Solubility
0.76 mg/L
Synvinolin State
Solid
Synvinolin LogP
4.937
Synvinolin Dosage Forms
Tablet (oral)
Synvinolin Indication
For the treatment of hypercholesterolemia.
Synvinolin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Synvinolin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Synvinolin side effects and Toxicity
No information avaliable
Synvinolin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Synvinolin Organisms Affected
Humans and other mammals
