Colemin
Colemin Brand names, Colemin Analogs
Colemin Brand Names Mixture
- No information avaliable
Colemin Chemical_Formula
C25H38O5
Colemin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Colemin fda sheet
Colemin msds (material safety sheet)
Colemin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Colemin Molecular Weight
418.566 g/mol
Colemin Melting Point
135-138oC
Colemin H2O Solubility
0.76 mg/L
Colemin State
Solid
Colemin LogP
4.937
Colemin Dosage Forms
Tablet (oral)
Colemin Indication
For the treatment of hypercholesterolemia.
Colemin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Colemin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Colemin side effects and Toxicity
No information avaliable
Colemin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Colemin Organisms Affected
Humans and other mammals
