Denan
Denan Brand names, Denan Analogs
Denan Brand Names Mixture
- No information avaliable
Denan Chemical_Formula
C25H38O5
Denan RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Denan fda sheet
Denan msds (material safety sheet)
Denan Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Denan Molecular Weight
418.566 g/mol
Denan Melting Point
135-138oC
Denan H2O Solubility
0.76 mg/L
Denan State
Solid
Denan LogP
4.937
Denan Dosage Forms
Tablet (oral)
Denan Indication
For the treatment of hypercholesterolemia.
Denan Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Denan Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Denan side effects and Toxicity
No information avaliable
Denan Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Denan Organisms Affected
Humans and other mammals
