Lodales
Lodales Brand names, Lodales Analogs
Lodales Brand Names Mixture
- No information avaliable
Lodales Chemical_Formula
C25H38O5
Lodales RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Lodales fda sheet
Lodales msds (material safety sheet)
Lodales Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Lodales Molecular Weight
418.566 g/mol
Lodales Melting Point
135-138oC
Lodales H2O Solubility
0.76 mg/L
Lodales State
Solid
Lodales LogP
4.937
Lodales Dosage Forms
Tablet (oral)
Lodales Indication
For the treatment of hypercholesterolemia.
Lodales Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Lodales Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Lodales side effects and Toxicity
No information avaliable
Lodales Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Lodales Organisms Affected
Humans and other mammals
