Vytorin
Vytorin Brand names, Vytorin Analogs
Vytorin Brand Names Mixture
- No information avaliable
Vytorin Chemical_Formula
C25H38O5
Vytorin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Vytorin fda sheet
Vytorin msds (material safety sheet)
Vytorin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Vytorin Molecular Weight
418.566 g/mol
Vytorin Melting Point
135-138oC
Vytorin H2O Solubility
0.76 mg/L
Vytorin State
Solid
Vytorin LogP
4.937
Vytorin Dosage Forms
Tablet (oral)
Vytorin Indication
For the treatment of hypercholesterolemia.
Vytorin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Vytorin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Vytorin side effects and Toxicity
No information avaliable
Vytorin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Vytorin Organisms Affected
Humans and other mammals
