Corolin
Corolin Brand names, Corolin Analogs
Corolin Brand Names Mixture
- No information avaliable
Corolin Chemical_Formula
C25H38O5
Corolin RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Corolin fda sheet
Corolin msds (material safety sheet)
Corolin Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Corolin Molecular Weight
418.566 g/mol
Corolin Melting Point
135-138oC
Corolin H2O Solubility
0.76 mg/L
Corolin State
Solid
Corolin LogP
4.937
Corolin Dosage Forms
Tablet (oral)
Corolin Indication
For the treatment of hypercholesterolemia.
Corolin Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Corolin Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Corolin side effects and Toxicity
No information avaliable
Corolin Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Corolin Organisms Affected
Humans and other mammals
