Nivelipol
Nivelipol Brand names, Nivelipol Analogs
Nivelipol Brand Names Mixture
- No information avaliable
Nivelipol Chemical_Formula
C25H38O5
Nivelipol RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Nivelipol fda sheet
Nivelipol msds (material safety sheet)
Nivelipol Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Nivelipol Molecular Weight
418.566 g/mol
Nivelipol Melting Point
135-138oC
Nivelipol H2O Solubility
0.76 mg/L
Nivelipol State
Solid
Nivelipol LogP
4.937
Nivelipol Dosage Forms
Tablet (oral)
Nivelipol Indication
For the treatment of hypercholesterolemia.
Nivelipol Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Nivelipol Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Nivelipol side effects and Toxicity
No information avaliable
Nivelipol Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Nivelipol Organisms Affected
Humans and other mammals
