Simovil
Simovil Brand names, Simovil Analogs
Simovil Brand Names Mixture
- No information avaliable
Simovil Chemical_Formula
C25H38O5
Simovil RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Simovil fda sheet
Simovil msds (material safety sheet)
Simovil Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Simovil Molecular Weight
418.566 g/mol
Simovil Melting Point
135-138oC
Simovil H2O Solubility
0.76 mg/L
Simovil State
Solid
Simovil LogP
4.937
Simovil Dosage Forms
Tablet (oral)
Simovil Indication
For the treatment of hypercholesterolemia.
Simovil Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Simovil Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Simovil side effects and Toxicity
No information avaliable
Simovil Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Simovil Organisms Affected
Humans and other mammals
