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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H24N2S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
312.473 g/mol
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Melting Point
64.5 oC
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H2O Solubility
0.693 mg/L
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State
Solid
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LogP
5.772
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Dosage Forms
Tablet (10 mg); Tablet (scored, 50 mg)
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Indication
For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
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Pharmacology
Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprothixene, thiothixene, loxapine, and haloperidol. Unlike other NMDA antagonists, ethopropazine — because of its anticholinergic action — is largely devoid of neurotoxic side effects. Ethopropazine also has a slight antihistaminic and local anesthetic effect.
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Absorption
Well-absorbed from the gastrointestinal tract.
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side effects and Toxicity
Symptoms of overdose include severe clumsiness or unsteadiness, severe drowsiness, severe dryness of mouth, nose, or throat, fast heartbeat, shortness of breath or troubled breathing, and warmth, dryness, and flushing of skin.
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Patient Information
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Organisms Affected
Humans and other mammals