Nortriptyline
Brand names,
Nortriptyline
Analogs
Nortriptyline
Brand Names Mixture
Nortriptyline
Chemical_Formula
C19H21N
Nortriptyline
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Nortriptyline
fda sheet
Nortriptyline
msds (material safety sheet)
Nortriptyline
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Nortriptyline
Molecular Weight
263.377 g/mol
Nortriptyline
Melting Point
213-215oC
Nortriptyline
H2O Solubility
No information avaliable
Nortriptyline
State
Solid
Nortriptyline
LogP
4.298
Nortriptyline
Dosage Forms
Capsules
Nortriptyline
Indication
For the treatment of depression.
Nortriptyline
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Nortriptyline
Absorption
Well absorbed from the GI tract.
Nortriptyline
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Nortriptyline
Patient Information
Nortriptyline
Organisms Affected
Humans and other mammals