Nortrilen
Brand names,
Nortrilen
Analogs
Nortrilen
Brand Names Mixture
Nortrilen
Chemical_Formula
C19H21N
Nortrilen
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Nortrilen
fda sheet
Nortrilen
msds (material safety sheet)
Nortrilen
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Nortrilen
Molecular Weight
263.377 g/mol
Nortrilen
Melting Point
213-215oC
Nortrilen
H2O Solubility
No information avaliable
Nortrilen
State
Solid
Nortrilen
LogP
4.298
Nortrilen
Dosage Forms
Capsules
Nortrilen
Indication
For the treatment of depression.
Nortrilen
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Nortrilen
Absorption
Well absorbed from the GI tract.
Nortrilen
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Nortrilen
Patient Information
Nortrilen
Organisms Affected
Humans and other mammals