Nortriptyline Hcl
Brand names,
Nortriptyline Hcl
Analogs
Nortriptyline Hcl
Brand Names Mixture
Nortriptyline Hcl
Chemical_Formula
C19H21N
Nortriptyline Hcl
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Nortriptyline Hcl
fda sheet
Nortriptyline Hcl
msds (material safety sheet)
Nortriptyline Hcl
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Nortriptyline Hcl
Molecular Weight
263.377 g/mol
Nortriptyline Hcl
Melting Point
213-215oC
Nortriptyline Hcl
H2O Solubility
No information avaliable
Nortriptyline Hcl
State
Solid
Nortriptyline Hcl
LogP
4.298
Nortriptyline Hcl
Dosage Forms
Capsules
Nortriptyline Hcl
Indication
For the treatment of depression.
Nortriptyline Hcl
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Nortriptyline Hcl
Absorption
Well absorbed from the GI tract.
Nortriptyline Hcl
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Nortriptyline Hcl
Patient Information
Nortriptyline Hcl
Organisms Affected
Humans and other mammals