Demethylamitryptyline
Brand names,
Demethylamitryptyline
Analogs
Demethylamitryptyline
Brand Names Mixture
Demethylamitryptyline
Chemical_Formula
C19H21N
Demethylamitryptyline
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Demethylamitryptyline
fda sheet
Demethylamitryptyline
msds (material safety sheet)
Demethylamitryptyline
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Demethylamitryptyline
Molecular Weight
263.377 g/mol
Demethylamitryptyline
Melting Point
213-215oC
Demethylamitryptyline
H2O Solubility
No information avaliable
Demethylamitryptyline
State
Solid
Demethylamitryptyline
LogP
4.298
Demethylamitryptyline
Dosage Forms
Capsules
Demethylamitryptyline
Indication
For the treatment of depression.
Demethylamitryptyline
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Demethylamitryptyline
Absorption
Well absorbed from the GI tract.
Demethylamitryptyline
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Demethylamitryptyline
Patient Information
Demethylamitryptyline
Organisms Affected
Humans and other mammals