Norzepine
Brand names,
Norzepine
Analogs
Norzepine
Brand Names Mixture
Norzepine
Chemical_Formula
C19H21N
Norzepine
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Norzepine
fda sheet
Norzepine
msds (material safety sheet)
Norzepine
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Norzepine
Molecular Weight
263.377 g/mol
Norzepine
Melting Point
213-215oC
Norzepine
H2O Solubility
No information avaliable
Norzepine
State
Solid
Norzepine
LogP
4.298
Norzepine
Dosage Forms
Capsules
Norzepine
Indication
For the treatment of depression.
Norzepine
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Norzepine
Absorption
Well absorbed from the GI tract.
Norzepine
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Norzepine
Patient Information
Norzepine
Organisms Affected
Humans and other mammals